SBML model for Mycobacterium-tuberculosis-H37Rv
Citations
D. Segre, J. Zucker, J. Katz, X. Lin, P. D'haeseleer, W. Rindone, P. Kharchenko, D. Nguyen, M. Wright, G. Church
"From annotated genomes to metabolic flux models and kinetic parameter fitting,"
OMICS 7:3 301-317 2003
P. Karp, S. Paley, and P. Romero
"The Pathway Tools Software,"
Bioinformatics 18:S225-32 2002
Description
The MTBRV model was generated from the Organism-specific Pathway/Genome database
Reaction Reaction Equation
EC# 3.6.1.34H<SUP>+</SUP><sub>[cytoplasm]</sub> + H<SUB>2</SUB>O + ATP =H<SUP>+</SUP><sub>[periplasm]</sub> + phosphate + ADP
EC# 1.17.4.-CDP + NrdH = dCDP + oxidized glutaredoxin + H<SUB>2</SUB>O
RXN0-724UTP + reduced flavodoxin = dUTP + oxidized flavodoxin + H<SUB>2</SUB>O
RXN0-723CTP + reduced flavodoxin = dCTP + oxidized flavodoxin + H<SUB>2</SUB>O
RXN0-743N<sup>5</sup>-carboxyaminoimidazole ribonucleotide = phosphoribosyl-carboxy-aminoimidazole
RXN0-7425'-phosphoribosyl-5-aminoimidazole + ATP + H<SUB>2</SUB>O + CO<SUB>2</SUB> = N<sup>5</sup>-carboxyaminoimidazole ribonucleotide + ADP + phosphate
RXN0-745ATP + reduced flavodoxin = deoxy-ATP + oxidized flavodoxin + H<SUB>2</SUB>O
RXN0-746GTP + reduced flavodoxin = deoxy-GTP + oxidized flavodoxin + H<SUB>2</SUB>O
RXN0-747ADP + NrdH = dADP + oxidized glutaredoxin + H<SUB>2</SUB>O
RXN0-748GDP + NrdH = dGDP + oxidized glutaredoxin + H<SUB>2</SUB>O
RXN1F-93dihydrokaempferol = kaempferol
RXN-527dihydroquercetin + NADH = quercetin + NAD
RXN1F-462quercetin + UDP-D-glucose = quercetin-3-glucoside + UDP
RXN-1541naringenin = isoflavone
RXN1G-186MSR + H<SUB>2</SUB>O = GlcN-Ins + AcCySR
RXN1G-129MSCH2OH + NAD + H<SUB>2</SUB>O -> formate + NADH + H + mycothiol
RXN1G-4Cys-GlcN-Ins + acetyl-CoA = mycothiol + Coenzyme A
COBINAMIDEKIN-RXNadenosylcobinamide + ATP = adenosylcobinamide-P + ADP
THIAZOLSYN2-RXNdeoxyxylulose-5-phosphate + ThiS-COSH + L-tyrosine = 4-methyl-5-(&beta;-hydroxyethyl)thiazole phosphate + 4-hydroxy-benzyl-alcohol + C1 of tyrosine + ThiS
EC# 1.1.1.-acetoacetyl-CoA + NADH = 3-hydroxybutyryl-CoA + NAD
DMK-RXN1,4-dihydroxy-2-naphthoate + polyprenylpyrophosphate = demethylmenaquinone + pyrophosphate + CO<SUB>2</SUB>
SHCHCSYNTH-RXNisochorismate + succinate-semialdehyde-thiamine PPi = 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate + pyruvate + CO<SUB>2</SUB>
GLYCOPHOSPHORYL-RXNGlycogens + phosphate = maltodextrin + glucose-1-phosphate
QUINOLINATE-SYNTHE-MULTI-RXNL-aspartate + O<SUB>2</SUB> + dihydroxy-acetone-phosphate = quinolinate + phosphate + H<SUB>2</SUB>O<SUB>2</SUB> + 2 H<SUB>2</SUB>O
EC# 2.-.-.-adenosylcobinamide-GDP + &alpha;-ribazole = adenosylcobalamin + GMP
R346-RXN1-amino-propan-2-ol + adenosyl-cobyric acid = adenosylcobinamide
ADOMET-DMK-METHYLTRANSFER-RXNdemethylmenaquinone + S-adenosyl-L-methionine = menaquinone + S-adenosyl-homocysteine
COBINPGUANYLYLTRANS-RXNadenosylcobinamide-P + GTP = adenosylcobinamide-GDP + pyrophosphate
PYRIMSYN1-RXN5'-phosphoribosyl-5-aminoimidazole = 4-amino-5-hydroxymethyl-2-methylpyrimidine-phosphate
ETFCLOS-RXNETF oxidized + NADH = ETF reduced + NAD
EC# 1.1.1.-acetaldehyde + NADH = ethanol + NAD
O-SUCCINYLBENZOATE-COA-SYN-RXN2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate = O-succinylbenzoate + H<SUB>2</SUB>O
MALTET-RXNmaltotetraose + H<SUB>2</SUB>O = maltotriose + &beta;-D-glucose
MALDEXPHOSPHORYL-RXNmaltodextrin + phosphate = maltotetraose + glucose-1-phosphate
GLYMALTOPHOSPHORYL-RXNGlycogens + phosphate = maltotetraose + glucose-1-phosphate
EC# 2.7.-.-adenosylcobinamide + ATP = adenosylcobinamide-P + ADP
EC# 1.-.-.-cob(II)yrinic acid a,c-diamide + NADH = cob(I)yrinic acid a,c-diamide + NAD
R342-RXNhydrogenobyrinate a,c-diamide + Co<SUP>2+</SUP> + ATP = cob(II)yrinic acid a,c-diamide + ADP + phosphate
EC# 1.-.-.-precorrin-3A = precorrin-3B
HYPXPRIBOSYLTRAN-RXNhypoxanthine + PRPP = pyrophosphate + IMP
EC# 2.4.2.-inosine + phosphate = ribose-1-phosphate + hypoxanthine
DEOXYINOPHOSPHOR-RXNhypoxanthine + deoxy-ribose-1-phosphate = deoxyinosine + phosphate
ADDALT-RXNNH<SUB>3</SUB> + deoxyinosine = H<SUB>2</SUB>O + deoxyadenosine
EC# 2.4.2.-ribose-1-phosphate + adenine = adenosine + phosphate
DEOXYADENPHOSPHOR-RXNdeoxyadenosine + phosphate = adenine + deoxy-ribose-1-phosphate
PDXJ-RXN1-amino-propan-2-one-3-phosphate + deoxyxylulose-5-phosphate = pyridoxine-5'-phosphate
PNPOXI-RXNO<SUB>2</SUB> + pyridoxine-5'-phosphate = H<SUB>2</SUB>O<SUB>2</SUB> + pyridoxal 5'-phosphate
PDXA-RXNphospho-hydroxy-threonine + NAD = 1-amino-propan-2-one-3-phosphate + NADH + CO<SUB>2</SUB>
DIMETHUROPORDEHYDROG-RXNdihydrosirohydrochlorin + NAD = sirohydrochlorin + NADH
alpha-ketoglutarate oxidative decarboxylation2-oxoglutarate + Coenzyme A + NAD = succinyl-CoA + CO<SUB>2</SUB> + NADH + H<SUP>+</SUP>
PYRUVDEH-RXNpyruvate + Coenzyme A + NAD = acetyl-CoA + CO<SUB>2</SUB> + NADH + H<SUP>+</SUP>
ACONITATEHYDR-RXNcis-aconitate + H<SUB>2</SUB>O = isocitrate
PHOSNACMURPENTATRANS-RXNundecaprenyl phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminoheptanedioate- D-alanyl-D-alanine = N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminoheptane- D-alanyl-D-alanine-diphosphoundecaprenol + UMP
EC# 2.7.1.-cytidine + GTP = CMP + GDP
2KETO-3METHYLVALERATE-RXN2-keto-3-methyl-valerate + NAD + Coenzyme A = 2-methylbutyryl-CoA + NADH + CO<SUB>2</SUB>
DALADEHYDROG-RXND-alanine + H<SUB>2</SUB>O = pyruvate + NH<SUB>3</SUB>
2TRANSKETO-RXNerythrose-4-phosphate + xylulose-5-phosphate = fructose-6-phosphate + glyceraldehyde-3-phosphate
EC# 5.-.-.-GDP-4-dehydro-6-deoxy-D-mannose = GDP-4-dehydro-6-L-deoxygalactose
EC# 1.-.-.-GDP-4-dehydro-6-L-deoxygalactose + NADPH + H<SUP>+</SUP> = guanosine diphosphate fucose + NADP
R41-RXN5-methyl-THF + B<SUB>12</SUB>-E = THF + methyl-B<SUB>12</SUB>-E
R42-RXNcarbon monoxide + Coenzyme A + methyl-B<SUB>12</SUB>-E = acetyl-CoA + B<SUB>12</SUB>-E
METLENETHFRED-FERRE-RXN5,10-methylene-THF + FdxA = 5-methyl-THF + oxidized ferredoxin
GDPMANMANHYDRO-RXNGDP-mannose + H<SUB>2</SUB>O = GDP + mannose
PHOSGLUCOSAMINEMUT-RXND-glucosamine-6-phosphate = glucosamine-1P
GLUCOSAMINE1PACETYL-RXNglucosamine-1P + acetyl-CoA = N-acetyl-glucosamine-1-phosphate + Coenzyme A
PROPIONYL-COA-CARBOXYLASE-RXNpropionyl-CoA + H<SUB>2</SUB>O + ATP + CO<SUB>2</SUB> = D-methylmalonyl-CoA + phosphate + ADP
ALPHA-KETOBUTYRATE-DEHYDROG-RXN2-oxobutanoate + Coenzyme A + NAD = propionyl-CoA + CO<SUB>2</SUB> + NADH
CYSTATHIONASE-RXNcystathionine + H<SUB>2</SUB>O = L-cysteine + homoserine
URA-PHOSPH-RXNphosphate + Deoxyuridine = deoxy-ribose-1-phosphate + uracil
AMACETOXID-RXNaminoacetone + H<SUB>2</SUB>O + O<SUB>2</SUB> = methyl-glyoxal + NH<SUB>3</SUB> + H<SUB>2</SUB>O<SUB>2</SUB>
METBALT-RXN2-oxobutanoate + succinate + NH<SUB>3</SUB> = O-succinyl-L-homoserine + H<SUB>2</SUB>O
HOMOSERDEAM-RXN2-oxobutanoate + NH<SUB>3</SUB> = homoserine
GCVMULTI-RXNL-glycine + THF + NAD = NH<SUB>3</SUB> + CO<SUB>2</SUB> + 5,10-methylene-THF + NADH + H<SUP>+</SUP>
FORMYLTHFGLUSYNTH-RXN10-formyl-THF(glu)<sub>n</sub> + L-glutamate + ATP = 10-formyl-THF(glu)<sub>n+1</sub> + ADP + phosphate
ACETYLSYNCLTH-RXNcarbon monoxide + [Co-E-CH<SUB>3</SUB>] + Coenzyme A = acetyl-CoA + [Co-E]
DURIDKI-RXNDeoxyuridine + ATP = dUMP + ADP
RIBOFLAVINSYNDEAM-RXNH<SUB>2</SUB>O + 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine = NH<SUB>3</SUB> + 5-amino-6-(ribosylamino)-2,4-(1H,3H)-pyrimidinedione 5'-phosphate
RIBOFLAVINSYNREDUC-RXNNADPH + H<SUP>+</SUP> + 5-amino-6-(ribosylamino)-2,4-(1H,3H)-pyrimidinedione 5'-phosphate = NADP + 5-amino-2,6-dioxy-4-(5'-phosphoribitylamino)pyrimidine
DIOHBUTANONEPSYN-RXNribulose-5-phosphate = 3,4-dihydroxy-2-butanone-4-P + formate
RIBOPHOSPHAT-RXN5-amino-2,6-dioxy-4-(5'-phosphoribitylamino)pyrimidine + H<SUB>2</SUB>O = 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione + phosphate
LUMAZINESYN-RXN3,4-dihydroxy-2-butanone-4-P + 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione = 6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate
LINE-RXNchlorohydroquinone + O<SUB>2</SUB> + H<SUB>2</SUB>O = maleylacetate + HCl
LIND-RXN2,5-dichlorohydroquinone + 2 reduced glutathione = chlorohydroquinone + oxidized glutathione + HCl
EC# 1.1.-.-2,5-dichloro-2,5-cyclohexadiene-1,4-diol + NAD = 2,5-dichlorohydroquinone + NADH + H<SUP>+</SUP>
3-OXOACYL-ACP-COA-SYNTHIII-RXNacetyl-CoA + malonyl-ACP = acetoacetyl-ACP + Coenzyme A + CO<SUB>2</SUB>
MALONYL-ACPDECARBOX-RXNmalonyl-ACP = acetyl-ACP + CO<SUB>2</SUB>
QUINOLINATE-SYNTHA-RXNiminoaspartate + dihydroxy-acetone-phosphate = quinolinate + 2 H<SUB>2</SUB>O + phosphate
UPPSYN-RXN<i>cis,trans</i>-polyisoprenyl<sub>n</sub>-PP + &Delta;<SUP>3</SUP>-isopentenyl-PP = pyrophosphate + <i>cis,trans</i>-polyisoprenyl<sub>n+1</sub>-PP
GDPPYPHOSKIN-RXNATP + GDP = AMP + guanosine 5'-diphosphate,3'-diphosphate
lactate oxidationFMN + lactate = FMNH<SUB>2</SUB> + pyruvate
PYRAMKIN-RXNATP + pyridoxamine = ADP + pyridoxamine 5'-phosphate
THIOREDOXIN-RXNReduced Thioredoxin = Oxidized Thioredoxin + 2 e<SUP>-</SUP>
GLUTAREDOXIN-RXNoxidized glutaredoxin + 2 e<SUP>-</SUP> = NrdH
nitrite reductase complexa reduced Cytochrome C552 protein + reduced cytochrome C552 + nitrite = an oxidized Cytochrome C552 protein + oxidized cytochrome C552 + NH<SUB>3</SUB>
THTOREDUCT-RXNtetrahydrothiophene 1-oxide + reduced acceptor = tetrahydrothiophene + acceptor
ENTMULTI-RXN6 ATP + 3 L-serine + 3 2,3-dihydroxybenzoate = 6 pyrophosphate + 6 AMP + enterobactin
FHLMULTI-RXNformate = CO<SUB>2</SUB> + H<SUB>2</SUB>
EC# 1.8.1.-PAPS + NADPH = SO<SUB>3</SUB> + adenosine 3',5'-bisphosphate + NADP
RXN1G-2GlcNAc-Ins = GlcN-Ins + acetate
RXN1G-121GlcN-Ins + ATP + L-cysteine = Cys-GlcN-Ins + ADP
RXN1G-6mycothiol + O = MSSM + H<SUB>2</SUB>O
RXN1G-7MSSM + NADPH = mycothiol + NADP
RXN1G-0mycothiol + RX = HX + MSR
EC# 6.1.1.11tRNA<SUP>ser</SUP> + L-serine + ATP = L-seryl-tRNA<SUP>ser</SUP> + pyrophosphate + AMP
EC# 6.1.1.6tRNA<SUP>lys</SUP> + L-lysine + ATP = L-lysyl-tRNA<SUP>lys</SUP> + pyrophosphate + AMP
EC# 6.1.1.16tRNA<SUP>cys</SUP> + L-cysteine + ATP = L-cysteinyl-tRNA<SUP>cys</SUP> + pyrophosphate + AMP
EC# 6.1.1.2tRNA<SUP>trp</SUP> + L-tryptophan + ATP = L-tryptophanyl-tRNA<SUP>trp</SUP> + pyrophosphate + AMP
EC# 6.1.1.15tRNA<SUP>pro</SUP> + L-proline + ATP = L-prolyl-tRNA<SUP>pro</SUP> + pyrophosphate + AMP
EC# 6.1.1.14tRNA<SUP>gly</SUP> + L-glycine + ATP = glycyl-tRNA<SUP>gly</SUP> + pyrophosphate + AMP
EC# 6.1.1.4tRNA<SUP>leu</SUP> + L-leucine + ATP = L-leucyl-tRNA<SUP>leu</SUP> + pyrophosphate + AMP
EC# 6.1.1.10tRNA<SUP>met</SUP> + L-methionine + ATP = L-methionyl-tRNA<SUP>met</SUP> + pyrophosphate + AMP
EC# 6.1.1.19tRNA<SUP>arg</SUP> + L-arginine + ATP = L-arginyl-tRNA<SUP>arg</SUP> + pyrophosphate + AMP
EC# 2.7.7.56a tRNA + phosphate + TRNA(N+1) = a ribonucleoside diphosphate + a tRNA + a ribonucleoside diphosphate + TRNA(N)
EC# 6.1.1.5tRNA<SUP>ile</SUP> + L-iso-leucine + ATP = L-isoleucyl-tRNA<SUP>ile</SUP> + pyrophosphate + AMP
EC# 6.1.1.20tRNA<SUP>phe</SUP> + L-phenylalanine + ATP = L-phenylalanyl-tRNA<SUP>phe</SUP> + pyrophosphate + AMP
EC# 6.1.1.1tRNA<SUP>tyr</SUP> + L-tyrosine + ATP = L-tyrosyl-tRNA<SUP>tyr</SUP> + pyrophosphate + AMP
EC# 6.1.1.9tRNA<SUP>val</SUP> + L-valine + ATP = L-valyl-tRNA<SUP>val</SUP> + pyrophosphate + AMP
EC# 6.1.1.7tRNA<SUP>ala</SUP> + L-alanine + ATP = L-alanyl-tRNA<SUP>ala</SUP> + pyrophosphate + AMP
EC# 6.1.1.12tRNA<SUP>asp</SUP> + L-aspartate + ATP = L-aspartyl-tRNA<SUP>asp</SUP> + pyrophosphate + AMP
EC# 6.1.1.21tRNA<SUP>his</SUP> + L-histidine + ATP = L-histidyl-tRNA<SUP>his</SUP> + pyrophosphate + AMP
EC# 6.1.1.3tRNA<SUP>thr</SUP> + L-threonine + ATP = L-threonyl-tRNA<SUP>thr</SUP> + pyrophosphate + AMP
EC# 2.5.1.8a tRNA + TRNA + &Delta;<SUP>3</SUP>-isopentenyl-PP = TRNA CONTAINING 6-ISOPENTENYLADENOSINE + pyrophosphate
EC# 2.1.1.31a tRNA + TRNA + S-adenosyl-L-methionine = TRNA CONTAINING N1-METHYLGUANINE + S-adenosyl-homocysteine
EC# 6.1.1.22tRNA<SUP>asn</SUP> + L-asparagine + ATP = L-asparaginyl-tRNA<SUP>asn</SUP> + pyrophosphate + AMP
EC# 6.1.1.18tRNA<SUP>gln</SUP> + L-glutamine + ATP = L-glutaminyl-tRNA<SUP>gln</SUP> + pyrophosphate + AMP
EC# 6.1.1.17tRNA<SUP>glt</SUP> + L-glutamate + ATP = L-glutamyl-tRNA<SUP>glt</SUP> + pyrophosphate + AMP
EC# 6.2.1.3Coenzyme A + a fatty acid + ATP = acyl-CoA + pyrophosphate + AMP
EC# 6.2.1.3octanoate + ATP + Coenzyme A = octanoyl-CoA + AMP + pyrophosphate
EC# 6.2.1.12Coenzyme A + 4-coumarate + ATP = coumaroyl-CoA + pyrophosphate + AMP
EC# 6.2.1.26ATP + O-succinylbenzoate + Coenzyme A = AMP + pyrophosphate + O-succinylbenzoyl-CoA
EC# 6.2.1.5succinyl-CoA + ADP + phosphate = succinate + Coenzyme A + ATP
EC# 6.2.1.1Coenzyme A + acetate + ATP = acetyl-CoA + pyrophosphate + AMP
EC# 6.2.1.9Coenzyme A + malate + ATP = phosphate + (3S)-3-Carboxy-3-hydroxypropanoyl-CoA + ADP
EC# 6.3.1.2NH<SUB>3</SUB> + L-glutamate + ATP = L-glutamine + ADP + phosphate
EC# 6.3.1.1NH<SUB>3</SUB> + L-aspartate + ATP = L-asparagine + pyrophosphate + AMP
EC# 6.3.1.5ATP + deamido-NAD + NH<SUB>3</SUB> = AMP + pyrophosphate + NAD
EC# 6.3.2.2L-cysteine + L-glutamate + ATP = L-&gamma;-glutamylcysteine + phosphate + ADP
EC# 6.3.2.1&beta;-alanine + L-pantoate + ATP = pantothenate + pyrophosphate + AMP
EC# 6.3.2.13UDP-N-acetylmuramoyl-L-alanyl-D-glutamate + meso-diaminopimelate + ATP = UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminoheptanedioate + phosphate + ADP
EC# 6.3.2.15D-alanyl-D-alanine + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminoheptanedioate + ATP = UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminoheptanedioate- D-alanyl-D-alanine + phosphate + ADP
EC# 6.3.2.9UDP-N-acetylmuramoyl-L-alanine + D-glutamate + ATP = UDP-N-acetylmuramoyl-L-alanyl-D-glutamate + phosphate + ADP
EC# 6.3.2.8L-alanine + UDP-N-acetylmuramate + ATP = UDP-N-acetylmuramoyl-L-alanine + phosphate + ADP
EC# 6.3.2.6ATP + phosphoribosyl-carboxy-aminoimidazole + L-aspartate = ADP + phosphate + 5'-phosphoribosyl-4-(N-succinocarboxamide)-5-aminoimidazole
EC# 6.3.2.17L-glutamate + H4PteGlu(n+1) + ATP = H4PteGlu(n) + phosphate + ADP
EC# 6.3.2.4D-alanine + D-alanine + ATP = D-alanyl-D-alanine + phosphate + ADP
EC# 6.3.2.3L-glycine + L-&gamma;-glutamylcysteine + ATP = reduced glutathione + phosphate + ADP
EC# 6.3.2.54'-phosphopantothenate + L-cysteine + CTP = pyrophosphate + CMP + 4'-phospho-N-pantothenoylcysteine
EC# 6.3.2.12L-glutamate + 7,8-dihydropteroate + ATP = 7,8-dihydrofolate + phosphate + ADP
EC# 6.3.3.3CO<SUB>2</SUB> + 7,8-diaminononanoate + ATP = dethiobiotin + phosphate + ADP
EC# 6.3.3.1ATP + 5-phosphoribosyl-n-formylglycineamidine = ADP + phosphate + 5'-phosphoribosyl-5-aminoimidazole
EC# 6.3.4.15AccB + biotin + ATP = pyrophosphate + AMP + BCCP-biotin
EC# 6.3.4.2L-glutamine + H<SUB>2</SUB>O + UTP + ATP = CTP + phosphate + ADP + L-glutamate
EC# 6.3.4.4L-aspartate + IMP + GTP = adenylo-succinate + phosphate + GDP
EC# 6.3.4.13ATP + 5-phosphoribosylamine + L-glycine = ADP + phosphate + 5-phospho-ribosyl-glycineamide
EC# 6.3.4.5L-aspartate + citrulline + ATP = L-arginino-succinate + pyrophosphate + AMP
EC# 6.3.4.1xanthosine-5-phosphate + ATP + NH<SUB>3</SUB> = AMP + pyrophosphate + GMP
EC# 6.3.4.3ATP + formate + THF = ADP + phosphate + 10-formyl-THF
EC# 6.3.4.14BCCP-biotin + CO<SUB>2</SUB> + ATP = phosphate + ADP + BCCP-biotin-CO<SUB>2</SUB>
EC# 6.3.4.16H<SUB>2</SUB>O + CO<SUB>2</SUB> + NH<SUB>3</SUB> + 2 ATP = phosphate + carbamoyl-phosphate + 2 ADP
EC# 6.3.5.2xanthosine-5-phosphate + H<SUB>2</SUB>O + L-glutamine + ATP = L-glutamate + GMP + pyrophosphate + AMP
EC# 6.3.5.-adenosyl-cobyrinic acid a,c-diamide + 4 L-glutamine + 4 ATP + 4 H<SUB>2</SUB>O = adenosyl-cobyric acid + 4 L-glutamate + 4 ADP + 4 phosphate
EC# 6.3.5.3ATP + 5'-phosphoribosyl-N-formylglycineamide + L-glutamine + H<SUB>2</SUB>O = ADP + phosphate + 5-phosphoribosyl-n-formylglycineamidine + L-glutamate
EC# 6.3.5.5H<SUB>2</SUB>O + HCO<SUB>3</SUB><SUP>-</SUP> + L-glutamine + 2 ATP + H<SUP>+</SUP> = carbamoyl-phosphate + L-glutamate + phosphate + 2 ADP
EC# 6.3.5.-hydrogenobyrinate + 2 L-glutamine + 2 ATP + 2 H<SUB>2</SUB>O = hydrogenobyrinate a,c-diamide + 2 L-glutamate + 2 ADP + 2 phosphate
EC# 6.3.5.4H<SUB>2</SUB>O + L-glutamine + L-aspartate + ATP = L-glutamate + L-asparagine + pyrophosphate + AMP
EC# 6.3.5.1ATP + deamido-NAD + L-glutamine + H<SUB>2</SUB>O = AMP + pyrophosphate + NAD + L-glutamate
EC# 6.4.1.3ATP + HCO<SUB>3</SUB><SUP>-</SUP> + propionyl-CoA = ADP + phosphate + D-methylmalonyl-CoA
EC# 6.4.1.1HCO<SUB>3</SUB><SUP>-</SUP> + pyruvate + ATP = phosphate + oxaloacetic acid + ADP
EC# 6.4.1.2BCCP-biotin-CO<SUB>2</SUB> + acetyl-CoA + ATP = malonyl-CoA + BCCP-biotin + phosphate + ADP
EC# 6.4.1.2HCO<SUB>3</SUB><SUP>-</SUP> + H<SUP>+</SUP> + acetyl-CoA + ATP = malonyl-CoA + phosphate + ADP
EC# 6.5.1.2(DEOXYRIBONUCLEOTIDE)(M) + (DEOXYRIBONUCLEOTIDE)(N) + NAD = (DEOXYRIBONUCLEOTIDE)(N+M) + nicotinamide nucleotide + AMP
EC# 5.-.-.-N-acetyl-D-mannosamine-6-phosphate = N-acetyl-D-glucosamine-6-phosphate
EC# 5.5.1.6naringenin chalcone = naringenin
EC# 5.5.1.23-Carboxy-cis,cis-muconate = 2-Carboxy-2,5-dihydro-5-oxofuran-2-acetate
EC# 5.5.1.1cis,cis-muconate = 2,5-Dihydro-5-oxofuran-2-acetate
EC# 5.99.1.2EC# 5.99.1.2
EC# 5.99.1.3EC# 5.99.1.3
EC# 5.1.1.1L-alanine = D-alanine
EC# 5.1.1.7ll-diaminopimelate = meso-diaminopimelate
EC# 5.1.1.3L-glutamate = D-glutamate
EC# 5.1.2.3D-3-hydroxyacyl-CoA = L-3-hydroxyacyl-CoA
EC# 5.1.3.13dTDP-4-dehydro-6-deoxy-D-glucose = dTDP-4-dehydro-6-deoxy-L-mannose
EC# 5.1.3.1ribulose-5-phosphate = xylulose-5-phosphate
EC# 5.1.3.2UDP-D-glucose = UDP-galactose
EC# 5.1.3.14UDP-N-acetyl-D-glucosamine = UDP-N-acetyl-D-mannosamine
EC# 5.1.99.1D-methylmalonyl-CoA = L-methylmalonyl-CoA
EC# 5.1.99.4(2S)-2-METHYLACYL-COA = (2R)-2-METHYLACYL-COA
EC# 5.2.1.8PEPTIDYLPROLINE (OMEGA=180) = PEPTIDYLPROLINE (OMEGA=0)
EC# 5.3.1.16phosphoribosylformiminoAICAR-phosphate = phosphoribulosylformimino-AICAR-P
EC# 5.3.1.1dihydroxy-acetone-phosphate = glyceraldehyde-3-phosphate
EC# 5.3.1.9glucose-6-phosphate = fructose-6-phosphate
EC# 5.3.1.8mannose-6-phosphate = fructose-6-phosphate
EC# 5.3.1.6ribose-5-phosphate = ribulose-5-phosphate
EC# 5.3.1.5&beta;-D-glucose = fructose
EC# 5.3.1.24N-(5'-phosphoribosyl)-anthranilate = 1-(o-carboxyphenylamino)-1'-deoxyribulose-5'-phosphate
EC# 5.3.3.8cis-&Delta;<SUP>3</SUP>-enoyl-CoA = trans-&Delta;<SUP>2</SUP>-enoyl-CoA
EC# 5.3.3.2&Delta;<SUP>3</SUP>-isopentenyl-PP = dimethylallyl-pyrophosphate
EC# 5.3.3.42,5-Dihydro-5-oxofuran-2-acetate = 3-oxoadipate-enol-lactone
EC# 5.4.1.2precorrin-8x = hydrogenobyrinate
EC# 5.4.2.2glucose-1-phosphate = glucose-6-phosphate
EC# 5.4.2.6&beta;-D-Glucose 1-phosphate = &beta;-D-Glucose 6-phosphate
EC# 5.4.2.8mannose-6-phosphate = mannose-1-phosphate
EC# 5.4.2.13-phosphoglycerate = 2-phosphoglycerate
EC# 5.4.2.7deoxy-ribose-1-phosphate = deoxyribose-5-phosphate
EC# 5.4.2.7ribose-1-phosphate = ribose-5-phosphate
EC# 5.4.3.8glutamate-1-semialdehyde = 5-amino-levulinate
EC# 5.4.99.9UDP-galactose = UDP-D-galacto-1,4-furanose
EC# 5.4.99.6chorismate = isochorismate
EC# 5.4.99.2L-methylmalonyl-CoA = succinyl-CoA
EC# 5.4.99.154-{(1,4)-alpha-D-glucosyl}(N-1)-D-glucose = 1-alpha-D-{(1,4)-alpha-D-glucosyl}(N-1)-alpha-D-glucopyranoside
EC# 5.4.99.5chorismate = prephenate
EC# 4.-.-.-4-amino-4-deoxychorismate = p-aminobenzoate + pyruvate
EC# 4.1.3.122-keto-isovalerate + acetyl-CoA + H<SUB>2</SUB>O = 3-carboxy-3-hydroxy-isocaproate + Coenzyme A
EC# 4.1.3.18pyruvate + 2-oxobutanoate = 2-aceto-2-hydroxy-butyrate + CO<SUB>2</SUB>
EC# 4.1.3.182 pyruvate = 2-aceto-lactate + CO<SUB>2</SUB>
EC# 4.1.3.6citrate = acetate + oxaloacetic acid
EC# 4.1.3.1isocitrate = glyoxylate + succinate
EC# 4.1.3.27chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate
EC# 4.1.3.-L-glutamine + chorismate = 4-amino-4-deoxychorismate + L-glutamate
EC# 4.1.3.36O-succinylbenzoyl-CoA = Coenzyme A + 1,4-dihydroxy-2-naphthoate
EC# 4.1.3.7oxaloacetic acid + acetyl-CoA + H<SUB>2</SUB>O = citrate + Coenzyme A
EC# 4.1.3.2acetyl-CoA + H<SUB>2</SUB>O + glyoxylate = malate + Coenzyme A
DXS-RXNpyruvate + glyceraldehyde-3-phosphate = CO<SUB>2</SUB> + deoxyxylulose-5-phosphate
EC# 4.1.3.-4-hydroxy-2-ketovalerate = acetaldehyde + pyruvate
EC# 4.1.3.24(3S)-3-Carboxy-3-hydroxypropanoyl-CoA = glyoxylate + acetyl-CoA
EC# 4.1.3.3N-acetylneuraminate = N-acetylmannosamine + pyruvate
EC# 4.1.3.16D-4-hydroxy-2-keto-glutarate = glyoxylate + pyruvate
EC# 4.1.1.-L-methylmalonyl-CoA = propionyl-CoA + CO<SUB>2</SUB>
EC# 4.1.1.15L-glutamate = CO<SUB>2</SUB> + 4-aminobutyrate
EC# 4.1.1.215'-phosphoribosyl-5-aminoimidazole + ATP + CO<SUB>2</SUB> + H<SUB>2</SUB>O = phosphate + phosphoribosyl-carboxy-aminoimidazole + ADP
EC# 4.1.1.37uroporphyrinogen-III = 4 CO<SUB>2</SUB> + coproporphyrinogen III
EC# 4.1.1.481-(o-carboxyphenylamino)-1'-deoxyribulose-5'-phosphate = indole-3-glycerol-phosphate + CO<SUB>2</SUB> + H<SUB>2</SUB>O
EC# 4.1.1.8oxalyl-CoA = CO<SUB>2</SUB> + formyl-CoA
EC# 4.1.1.23orotidine-5'-phosphate = CO<SUB>2</SUB> + UMP
EC# 4.1.1.65L-1-phosphatidylserine = L-1-phosphatidyl-ethanolamine + CO<SUB>2</SUB>
EC# 4.1.1.20meso-diaminopimelate = CO<SUB>2</SUB> + L-lysine
EC# 4.1.1.11L-aspartate = &beta;-alanine + CO<SUB>2</SUB>
EC# 4.1.1.4acetoacetate = CO<SUB>2</SUB> + acetone
EC# 4.1.1.712-oxoglutarate + thiamine-pyrophosphate = CO<SUB>2</SUB> + succinate-semialdehyde-thiamine PPi
EC# 4.1.1.32oxaloacetic acid + GTP = CO<SUB>2</SUB> + phosphoenolpyruvate + GDP
EC# 4.1.1.31phosphoenolpyruvate + H<SUB>2</SUB>O + CO<SUB>2</SUB> = phosphate + oxaloacetic acid
EC# 4.1.1.364'-phospho-N-pantothenoylcysteine = pantetheine 4'-phosphate + CO<SUB>2</SUB>
EC# 4.1.1.18L-lysine = CO<SUB>2</SUB> + cadaverine
EC# 4.1.1.49oxaloacetic acid + ATP = CO<SUB>2</SUB> + phosphoenolpyruvate + ADP
EC# 4.1.1.17L-ornithine = CO<SUB>2</SUB> + putrescine
EC# 4.1.1.19L-arginine = CO<SUB>2</SUB> + agmatine
EC# 4.1.1.442-Carboxy-2,5-dihydro-5-oxofuran-2-acetate = CO<SUB>2</SUB> + 3-oxoadipate-enol-lactone
EC# 4.1.1.41D-methylmalonyl-CoA = CO<SUB>2</SUB> + propionyl-CoA
EC# 4.1.1.74Indolepyruvate = CO<SUB>2</SUB> + indole acetaldehyde
EC# 4.1.1.50S-adenosyl-L-methionine = CO<SUB>2</SUB> + S-adenosylmethioninamine
EC# 4.1.2.13fructose-1,6-bisphosphate = dihydroxy-acetone-phosphate + glyceraldehyde-3-phosphate
EC# 4.1.2.4deoxyribose-5-phosphate = acetaldehyde + glyceraldehyde-3-phosphate
EC# 4.1.2.15phosphoenolpyruvate + erythrose-4-phosphate + H<SUB>2</SUB>O = 3-deoxy-D-arabino-heptulosonate-7-phosphate + phosphate
EC# 4.1.2.25dihydro-neo-pterin = glycolaldehyde + 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine
EC# 4.1.2.9phosphate + xylulose-5-phosphate = H<SUB>2</SUB>O + glyceraldehyde-3-phosphate + acetylphosphate
EC# 4.2.1.51prephenate = phenylpyruvate + H<SUB>2</SUB>O + CO<SUB>2</SUB>
EC# 4.2.1.46dTDP-D-glucose = H<SUB>2</SUB>O + dTDP-4-dehydro-6-deoxy-D-glucose
EC# 4.2.1.173-hydroxybutyryl-CoA = crotonyl-CoA + H<SUB>2</SUB>O
EC# 4.2.1.17H<SUB>2</SUB>O + trans-&Delta;<SUP>2</SUP>-enoyl-CoA = L-3-hydroxyacyl-CoA
EC# 4.2.1.17tiglyl-CoA + H<SUB>2</SUB>O = 2-methyl-3-hydroxybutyryl-CoA
EC# 4.2.1.17methacrylyl-CoA + H<SUB>2</SUB>O = 3-hydroxy-isobutyryl-CoA
EC# 4.2.1.70ribose-5-phosphate + uracil = H<SUB>2</SUB>O + pseudouridine 5'-phosphate
EC# 4.2.1.333-carboxy-3-hydroxy-isocaproate = 2-D-threo-hydroxy-3-carboxy-isocaproate
EC# 4.2.1.52pyruvate + L-aspartate-semialdehyde = 2 H<SUB>2</SUB>O + 2,3-dihydrodipicolinate
EC# 4.2.1.20indole-3-glycerol-phosphate + L-serine = L-tryptophan + H<SUB>2</SUB>O + glyceraldehyde-3-phosphate
EC# 4.2.1.19D-erythro-imidazole-glycerol-phosphate = imidazole acetol-phosphate + H<SUB>2</SUB>O
EC# 4.2.1.3citrate = cis-aconitate + H<SUB>2</SUB>O
EC# 4.2.1.112-phosphoglycerate = phosphoenolpyruvate + H<SUB>2</SUB>O
EC# 4.2.1.13L-serine + H<SUB>2</SUB>O = pyruvate + NH<SUB>3</SUB> + H<SUB>2</SUB>O
EC# 4.2.1.92,3-dihydroxy-3-methylvalerate = 2-keto-3-methyl-valerate + H<SUB>2</SUB>O
EC# 4.2.1.242 5-amino-levulinate = 2 H<SUB>2</SUB>O + porphobilinogen
EC# 4.2.1.22homocysteine + L-serine = H<SUB>2</SUB>O + cystathionine
EC# 4.2.1.2malate = fumarate + H<SUB>2</SUB>O
EC# 4.2.1.47GDP-mannose = H<SUB>2</SUB>O + GDP-4-dehydro-6-deoxy-D-mannose
EC# 4.2.1.16L-threonine + H<SUB>2</SUB>O = 2-oxobutanoate + H<SUB>2</SUB>O + NH<SUB>3</SUB>
EC# 4.2.1.103-dehydroquinate = H<SUB>2</SUB>O + 3-dehydro-shikimate
EC# 4.2.1.1H<SUB>2</SUB>O + CO<SUB>2</SUB> = H<SUB>2</SUB>CO<SUB>3</SUB>
EC# 4.2.1.553-hydroxybutyryl-CoA = H<SUB>2</SUB>O + crotonyl-CoA
EC# 4.2.1.75hydroxymethylbilane = H<SUB>2</SUB>O + uroporphyrinogen-III
EC# 4.2.1.92,3-dihydroxy-isovalerate = 2-keto-isovalerate + H<SUB>2</SUB>O
EC# 4.2.1.60D-3-hydroxy-acyl-ACP = trans-&Delta;<SUP>2</SUP>-enoyl-acyl-ACP + H<SUB>2</SUB>O
EC# 4.2.99.10methanethiol + O-Acetyl-L-homoserine = acetate + L-methionine
EC# 4.2.99.9L-cysteine + O-succinyl-L-homoserine = succinate + cystathionine
EC# 4.2.99.8O-acetyl-L-serine + H<SUB>2</SUB>S = L-cysteine + acetate
EC# 4.2.99.18EC# 4.2.99.18
EC# 4.2.99.-L-cysteine + O-phospho-L-homoserine = cystathionine + phosphate
EC# 4.2.99.-O-Acetyl-L-homoserine + H<SUB>2</SUB>S = homocysteine + acetate
EC# 4.2.99.2O-phospho-L-homoserine + H<SUB>2</SUB>O = phosphate + L-threonine
EC# 4.6.1.33-deoxy-D-arabino-heptulosonate-7-phosphate = phosphate + 3-dehydroquinate
EC# 4.6.1.45-enolpyruvyl-shikimate-3-phosphate = phosphate + chorismate
EC# 4.3.1.8H<SUB>2</SUB>O + 4 porphobilinogen = 4 NH<SUB>3</SUB> + hydroxymethylbilane
EC# 4.3.1.1L-aspartate = fumarate + NH<SUB>3</SUB>
EC# 4.3.2.25'-phosphoribosyl-4-(N-succinocarboxamide)-5-aminoimidazole = fumarate + AICAR
EC# 4.3.2.1L-arginino-succinate = L-arginine + fumarate
EC# 4.3.2.2adenylo-succinate = fumarate + AMP
EC# 4.3.2.3(S)-Ureidoglycolate = urea + glyoxylate
EC# 4.3.99.1HCO<SUB>3</SUB><SUP>-</SUP> + Cyanate = carbamate + CO<SUB>2</SUB>
EC# 4.4.1.-homoserine + H<SUB>2</SUB>O = 2-oxobutanoate + NH<SUB>4</SUB><SUP>+</SUP> + H<SUB>2</SUB>O
EC# 4.4.1.8cystathionine + H<SUB>2</SUB>O = pyruvate + NH<SUB>3</SUB> + homocysteine
EC# 4.4.1.1cystathionine + H<SUB>2</SUB>O = 2-oxobutanoate + L-cysteine + NH<SUB>3</SUB>
EC# 4.5.1.-&gamma;-pentachlorocyclohexane = HCl + 1,3,4,6-tetrachloro-1,4-cyclohexadiene
EC# 4.5.1.-&gamma;-hexachlorocyclohexane = &gamma;-pentachlorocyclohexane + HCl
EC# 4.99.1.1Fe<SUP>2+</SUP> + protoporphyrin IX = 2 H<SUP>+</SUP> + protoheme
EC# 4.99.1.-sirohydrochlorin + Fe<SUP>2+</SUP> = siroheme + 2 H<SUP>+</SUP>
EC# 4.99.1.2phenylmercury acetate + H<SUP>+</SUP> = Hg<SUP>2+</SUP> + benzene + acetate
EC# 3.1.26.5EC# 3.1.26.5
EC# 3.1.26.4EC# 3.1.26.4
EC# 3.1.26.3EC# 3.1.26.3
EC# 3.1.3.12&alpha;,&alpha;-trehalose 6-phosphate + H<SUB>2</SUB>O = trehalose + phosphate
EC# 3.1.3.2an orthophosphoric monoester + H<SUB>2</SUB>O + an orthophosphoric monoester = phosphate + an alcohol
EC# 3.1.3.33-phospho-serine + H<SUB>2</SUB>O = L-serine + phosphate
EC# 3.1.3.16H<SUB>2</SUB>O + A PHOSPHOPROTEIN = a protein + phosphate + a protein
EC# 3.1.3.1an orthophosphoric monoester + an orthophosphoric monoester + H<SUB>2</SUB>O = an alcohol + phosphate
EC# 3.1.3.25H<SUB>2</SUB>O + 1L-myo-Inositol 1-phosphate = phosphate + <I>myo</I>-inositol
EC# 3.1.3.48a protein tyrosine phosphate + H<SUB>2</SUB>O + a protein tyrosine phosphate = a protein tyrosine + phosphate + a protein tyrosine
EC# 3.1.3.-H<SUB>2</SUB>O + &alpha;-ribazole-5'-P = &alpha;-ribazole + phosphate
EC# 3.1.3.11fructose-1,6-bisphosphate + H<SUB>2</SUB>O = fructose-6-phosphate + phosphate
EC# 3.1.3.15L-histidinol-phosphate + H<SUB>2</SUB>O = histidinol + phosphate
EC# 3.1.3.10H<SUB>2</SUB>O + glucose-1-phosphate = phosphate + &beta;-D-glucose
EC# 3.1.3.27L-1-phosphatidylglycerol-phosphate + H<SUB>2</SUB>O = L-1-phosphatidyl-glycerol + phosphate
EC# 3.1.3.4H<SUB>2</SUB>O + L-phosphatidate = phosphate + 1,2-diacylglycerol
EC# 3.1.3.-H<SUB>2</SUB>O + NADP = NAD + phosphate
EC# 3.1.4.46H<SUB>2</SUB>O + a glycerophosphodiester = glycerol-3-phosphate + an alcohol
EC# 3.1.4.3Lecithins + phosphatidylcholine + H<SUB>2</SUB>O = phosphoryl-choline + 1,2-diacylglycerol
EC# 3.1.5.1H<SUB>2</SUB>O + deoxy-GTP = PPP<SUB>i</SUB> + deoxyguanosine
EC# 3.1.6.1an aromatic sulfate + H<SUB>2</SUB>O + an aromatic sulfate = SO<SUB>4</SUB><SUP>2-</SUP> + an aryl alcohol
EC# 3.1.7.2guanosine 5'-diphosphate,3'-diphosphate + H<SUB>2</SUB>O = pyrophosphate + GDP
EC# 3.1.1.29H<SUB>2</SUB>O + N-SUBSTITUTED AMINOACYL-TRNA = a N-substituted amino acid + a tRNA + TRNA + N-SUBSTITUTED AMINO ACID
EC# 3.1.1.1H<SUB>2</SUB>O + A CARBOXYLIC ESTER = an acid + an alcohol
EC# 3.1.1.24H<SUB>2</SUB>O + 3-oxoadipate-enol-lactone = 3-ketoadipate
EC# 3.1.1.31D-6-phospho-glucono-&delta;-lactone + H<SUB>2</SUB>O = 6-phospho-gluconate
EC# 3.1.11.2EC# 3.1.11.2
EC# 3.1.11.6EC# 3.1.11.6
EC# 3.1.2.-acyl-CoA + H<SUB>2</SUB>O = a fatty acid + Coenzyme A
EC# 3.1.2.4H<SUB>2</SUB>O + 3-hydroxy-isobutyryl-CoA = 3-hydroxy-isobutyrate + Coenzyme A
EC# 3.2.1.4EC# 3.2.1.4
EC# 3.2.1.21EC# 3.2.1.21
EC# 3.2.1.141EC# 3.2.1.141
EC# 3.2.1.20EC# 3.2.1.20
EC# 3.2.1.11,4-&alpha;-D-glucan = maltodextrin
EC# 3.2.1.68maltodextrin = maltotetraose
EC# 3.2.1.23H<SUB>2</SUB>O + lactose = &beta;-D-galactose + &beta;-D-glucose
EC# 3.2.1.39EC# 3.2.1.39
EC# 3.2.2.20EC# 3.2.2.20
EC# 3.2.2.21EC# 3.2.2.21
EC# 3.2.2.23EC# 3.2.2.23
EC# 3.2.2.4H<SUB>2</SUB>O + AMP = ribose-5-phosphate + adenine
EC# 3.2.2.1nicotinamide ribose + H<SUB>2</SUB>O = niacinamide + ribose
EC# 3.3.2.3H<SUB>2</SUB>O + AN EPOXIDE = A GLYCOL
EC# 3.3.2.1H<SUB>2</SUB>O + isochorismate = pyruvate + 2,3-dihydro-2,3-dihydroxybenzoate
EC# 3.3.1.1H<SUB>2</SUB>O + S-adenosyl-homocysteine = homocysteine + adenosine
EC# 3.4.11.18EC# 3.4.11.18
EC# 3.4.11.5EC# 3.4.11.5
EC# 3.4.19.3H<SUB>2</SUB>O + 5-OXOPROLYL-PEPTIDE = PEPTIDE + 5-OXOPROLYL
EC# 3.4.21.83EC# 3.4.21.83
EC# 3.4.21.89EC# 3.4.21.89
EC# 3.4.23.36EC# 3.4.23.36
EC# 3.4.24.57EC# 3.4.24.57
EC# 3.5.1.25H<SUB>2</SUB>O + N-acetyl-D-glucosamine-6-phosphate = acetate + D-glucosamine-6-phosphate
EC# 3.5.1.31H<SUB>2</SUB>O + N-formyl-L-methionine = L-methionine + formate
EC# 3.5.1.18H<SUB>2</SUB>O + N-succinyl-LL-2,6-diaminopimelate = ll-diaminopimelate + succinate
EC# 3.5.1.5H<SUB>2</SUB>O + urea = 2 NH<SUB>3</SUB> + CO<SUB>2</SUB>
EC# 3.5.1.10H<SUB>2</SUB>O + 10-formyl-THF = THF + formate
EC# 3.5.1.1L-asparagine + H<SUB>2</SUB>O = L-aspartate + NH<SUB>3</SUB>
EC# 3.5.1.-pyrazinamide + H<SUB>2</SUB>O = pyrazinoic acid + NH<SUB>3</SUB>
EC# 3.5.1.19niacinamide + H<SUB>2</SUB>O = niacine + NH<SUB>3</SUB>
EC# 3.5.2.3carbamoyl-L-aspartate = dihydroorotate + H<SUB>2</SUB>O
EC# 3.5.2.5H<SUB>2</SUB>O + allantoin = allantoate
EC# 3.5.2.6a &beta;-lactam + H<SUB>2</SUB>O + a &beta;-lactam = A SUBSTITUTED BETA-AMINO ACID
EC# 3.5.3.92 H<SUB>2</SUB>O + 2 allantoate = O<SUB>2</SUB> + 2 CO<SUB>2</SUB> + 2 NH<SUB>3</SUB> + 2 ureidoglycine
EC# 3.5.3.6H<SUB>2</SUB>O + L-arginine = NH<SUB>3</SUB> + citrulline
EC# 3.5.3.19H<SUB>2</SUB>O + (S)-Ureidoglycolate = CO<SUB>2</SUB> + 2 NH<SUB>3</SUB> + glyoxylate
EC# 3.5.3.4H<SUB>2</SUB>O + allantoate = (S)-Ureidoglycolate + urea
EC# 3.5.3.11H<SUB>2</SUB>O + agmatine = urea + putrescine
EC# 3.5.4.162 H<SUB>2</SUB>O + GTP = dihydroneopterin triphosphate + formate
EC# 3.5.4.9H<SUB>2</SUB>O + 5,10-methenyl-THF = 10-formyl-THF
EC# 3.5.4.5H<SUB>2</SUB>O + cytidine = NH<SUB>3</SUB> + uridine
EC# 3.5.4.5H<SUB>2</SUB>O + deoxycytidine = NH<SUB>3</SUB> + Deoxyuridine
EC# 3.5.4.4H<SUB>2</SUB>O + adenosine = NH<SUB>3</SUB> + inosine
EC# 3.5.4.13H<SUB>2</SUB>O + dCTP = NH<SUB>3</SUB> + dUTP
EC# 3.5.4.253 H<SUB>2</SUB>O + GTP = pyrophosphate + 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine + formate
EC# 3.5.4.19phosphoribosyl-AMP + H<SUB>2</SUB>O = phosphoribosylformiminoAICAR-phosphate
EC# 3.5.4.10phosphoribosyl-formamido-carboxamide = IMP + H<SUB>2</SUB>O
EC# 3.5.4.1H<SUB>2</SUB>O + cytosine = NH<SUB>3</SUB> + uracil
EC# 3.5.4.26H<SUB>2</SUB>O + 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine = NH<SUB>3</SUB> + 5-Amino-6-(5'-phosphoribosylamino)uracil
EC# 5.3.1.10H<SUB>2</SUB>O + D-glucosamine-6-phosphate = NH<SUB>3</SUB> + fructose-6-phosphate
EC# 3.6.1.1H<SUB>2</SUB>O + pyrophosphate = 2 phosphate
EC# 3.6.1.36H<SUB>2</SUB>O + ATP = phosphate + ADP
EC# 3.6.1.34H<SUP>+</SUP><sub>[cytoplasm]</sub> + H<SUB>2</SUB>O + ATP =H<SUP>+</SUP><sub>[periplasm]</sub> + phosphate + ADP
EC# 3.6.1.26CDP-diacylglycerol + H<SUB>2</SUB>O = CMP + L-phosphatidate
EC# 3.6.1.23H<SUB>2</SUB>O + dUTP = pyrophosphate + dUMP
EC# 3.6.1.-dihydroneopterin triphosphate = dihydroneo